In recent years, many people have turned to natural dietary supplements (aka “hunger pills”) to help control their appetite and manage weight. While some supplements have little to no scientific evidence supporting their claims, others have demonstrated effectiveness in suppressing appetite. In this post, we’ll look at some of the best selling appetite control pills, their ingredients and the scientific research that may or may not support the claims.
Jacked Factory “Burn-XT” Pills
Jacked Factory is a Canadian nutrition & health supplement brand established in 2014. Their “Burn-XT” pills is the #1 best selling appetite control and suppressants on Amazon, with an impressive 73,000 ratings.
Jacked Factory “Burn XT” is designed to support weight loss efforts by increasing energy, focus, and metabolic rate while suppressing appetite. It contains scientifically studied ingredients such as acetyl L-Carnitine, Green Tea Extract, Caffeine, and Cayenne Pepper Extract. It aims to assist an active lifestyle and help individuals reach their fitness goals when combined with a healthy diet and exercise plan.
*60 capsules at $34.99; 120 capsules at $54.99
All prices in the article are as of time of writing.
Burn-XT is manufactured in a cGMP facility in the USA (instead of Canada, interestingly), ensuring purity, potency, and authenticity. The supplement is not a miracle pill, but it may provide weight loss support for those who use it consistently over a period of time. Jacked Factory also offers a 30-day money-back guarantee for those who are not satisfied with the results.
Ingredients
| Ingredients | Per Capsule |
|---|---|
| Acetyl L-Carnitine HCL | 350mg |
| Green Tea Leaf Extract | 225mg |
| Caffeine Anhydrous | 135mg |
| Capsimax(R) Cayenne Pepper Fruit Extract | 25mg |
| Bioperine(R) Black Pepper Fruit Extract | 2.5mg |
Key Benefits
- Appetite suppression: Some of its ingredients, particularly Acetyl L-Carnitine HCL, may help reduce feelings of hunger and cravings, making it easier to stick to a healthy diet plan.
- Weight loss: Burn-XT contains multiple ingredients (eg. Green Tea Extract and Cayenne Pepper Extract ) that have been clinically studied to support weight loss when used in conjunction with a healthy diet and exercise plan.
- Increased energy and focus: Some of its ingredients, particularly Caffeine, may increase energy levels and improve focus and concentration.
- Improved metabolism: Green Tea Extract, Cayenne Pepper Extract and Black Pepper Extract all contain compounds that may help boost metabolism and increase the body’s ability to burn calories.
- Preservation of muscle tissue: Acetyl L-Carnitine HCL can also help preserve muscle tissue by supporting healthy energy production and reducing muscle damage during exercise. This can be especially important during weight loss efforts, as losing muscle tissue can lead to a slower metabolism and make it more difficult to maintain weight loss in the long term.
How to Use
- Start with 1 capsule, once a day with meal & water for 1 week to assess tolerance.
- For regular use, you can take 1 capsule, twice a day with meal & water.
Scientific Research
Acetyl L-Carnitine HCL
Acetyl L-Carnitine HCL is a compound that is naturally produced in the body and also found in some foods. It is often used as a dietary supplement and has been studied for its potential health benefits, including weight and appetite control, especially in adults with overweight/obesity.
In a 2020 meta-analysis published on Clinical Nutrition ESPEN, the official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN), researchers analyzed 37 randomized controlled trials with a total of 2292 participants. They found that l-carnitine supplementation significantly reduced body weight, body mass index (BMI), and fat mass. They also found a non-linear dose-response association between l-carnitine supplementation and body weight reduction, suggesting that ingestion of 2000 mg l-carnitine per day provides the maximum effect in adults [1] Trusted Website Official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Open the link → .
Green Tea Leaf Extract
The main active ingredient of Green Tea Extract is EGCG (Epigallocatechin Gallate), which is a type of catechin. EGCG has strong antioxidant and anti-inflammatory properties, which may protect cells from damage, suppress the activity of pro-inflammatory chemicals, and reduce the risk of chronic diseases such as heart disease, cancer, and diabetes; EGCG may also promote weight loss, especially when taken alongside caffeine, and may improve neurological cell function and prevent degenerative brain diseases.
(Image: VIXI at Amazon)
In 2009, a study was conducted in the Netherlands to investigate the effects of green tea on weight loss and weight maintenance. The study involved 104 overweight or obese women and lasted for 12 weeks. The subjects were given either green tea or a placebo, and they followed a weight-loss diet. The results indicated that the consumption of green tea significantly increased weight loss and helped maintain the reduced weight [2] Trusted Website Nature.com is a trusted source of scientific research, news, and reviews. Open the link → .
A meta-analysis in 2013 analyzed the effect of green tea consumption on weight loss and weight maintenance. The researchers analyzed 14 randomized controlled trials involving a total of 1,945 subjects. The results showed that green tea had a positive impact on weight loss and weight maintenance [3] Trusted Website Nature.com is a trusted source of scientific research, news, and reviews. Open the link → .
Caffeine Anhydrous
Caffeine anhydrous is a concentrated, powdered form of caffeine that is commonly used to improve alertness and mental focus.
In 2011, a meta-analysis was conducted to analyze the effect of caffeine on energy expenditure and weight loss. The researchers reviewed 13 studies involving a total of 606 subjects. The results showed that caffeine intake was associated with increased energy expenditure and weight loss [4] Trusted Website Wiley.com is a U.S. publishing company that specializes in academic content with 200 years of history. Open the link → .
Cayenne Pepper Fruit Extract
Cayenne Pepper Extract is a concentrated liquid or powder made from chili pepper, commonly used in cooking and for its potential health benefits.
(Image: Isla’s garden seeds store at Amazon)
In 2012, a study conducted at Manchester Metropolitan University in the UK explored the effects of Capsaicinoids, such as those found in Cayenne Pepper Extract, on weight management. The meta-analysis reviewed 20 studies involving a total of 563 participants. The results showed that Capsaicinoids intake increased energy expenditure and reduced appetite, which could be beneficial for weight loss and weight maintenance [5] Trusted Website ScienceDirect.com is a trusted database of scientific and medical publications. Open the link → .
Black Pepper Fruit Extract
Bioperine(R) is a standardized extract of black pepper that is commonly used as a dietary supplement ingredient. Bioperine(R) contains an active compound called piperine, which is believed to increase the bioavailability of a variety of nutrients, including vitamins, minerals, amino acids, and herbal extracts.
In a 2022 study published on Current Research in Food Science, the researchers used an obese mouse model to investigate the effects of piperine on gut microbiota (GM), which can impact obesity. Piperine was given at two different doses and the results showed that the higher dose significantly reduced body weight, liver weight, and perirenal fat weight, as well as improving cholesterol and glucose levels. The results suggest that piperine could potentially be used to improve weight and appetite control [6] Trusted Website ScienceDirect.com is a trusted database of scientific and medical publications. Open the link → .
Potential Side Effects
- It may cause stomach upset, nausea, vomiting, headache, and discomfort from Acetyl-L-Carnitine HCL.
- It may cause irritability, nervousness, sleeplessness, nausea, increased blood sugar, and rapid heart beat from high Caffeine content.
- It may cause rash, hives, or swelling from an allergic reaction.
- You may experience jitters & restlessness as your body adjusts to the ingredients & caffeine.
HUM Skinny Bird(R)
HUM Nutrition is a California-based supplements company founded in 2012. Its Skinny Bird(R) is a dietary supplement designed to support healthy weight management by curbing appetite and supporting balanced blood sugar levels within normal ranges. The formula contains Caralluma, which helps to make you feel fuller for longer, 5-HTP to balance mood and control stress eating, and Chromium for blood sugar support and reduced cravings.
The supplement is made with clinically proven nutrients and verified clean ingredients, free of artificial colors, sweeteners, flavors, and preservatives.
Ingredients
| Ingredients | Per Serving |
|---|---|
| Caralluma fimbriata extract | 333mg |
| Chromium | 200mcg |
| 5-HTP (from Griffonia simplicifolia, seed) | 100mg |
| Green tea extract (leaf, 50% caffeine) | 66mg |
Key Benefits
- Helps curb appetite
- Supports healthy blood sugar levels already within normal ranges
- Helps reduce stress eating
Scientific Research
Caralluma Fimbriata Extract
Caralluma Fimbriata Extract is made from a popular edible cactus in India. It’s believed to have appetite-suppressing and weight loss properties.
(Image: JAGREX at Amazon India)
In a 12-week trial in Australia, 33 overweight or obese adults were randomly assigned to either receive Caralluma Fimbriata Extract or a placebo while following a reduced-calorie diet and exercise plan. The group taking Caralluma experienced a decrease in appetite of food and sodium intake, and had a greater decrease in waist circumference and waist-to-hip ratio compared to the placebo group [7] Trusted Website ScienceDirect.com is a trusted database of scientific and medical publications. Open the link → .
A 2006 study investigated the effect of Caralluma Fimbriata Extract on appetite and food intake in overweight Indian adults. Fifty men and women with a BMI over 25 kg/m2 were randomly assigned to either receive a daily dose of Caralluma extract or a placebo for 60 days, while following a weight-reducing diet and physical activity guidelines. At the end of the study, the experimental group showed a significant decline in waist circumference and hunger levels compared to the placebo group, suggesting that Caralluma extract may help suppress appetite and reduce weight [8] Trusted Website ScienceDirect.com is a trusted database of scientific and medical publications. Open the link → .
Chromium
Chromium is a mineral that has been shown to play a role in glucose intolerance, type 2 diabetes, and gestational diabetes.
A review of studies in 2000 found that supplementing with 200mcg/day of chromium appears to help balance already healthy blood sugar levels in people without diabetes [9].
5-HTP
5-HTP is a natural amino acid precursor that is used by the body to produce serotonin, a neurotransmitter that regulates mood, appetite, and sleep.
A study conducted in 1989 in Italy investigated the effects of 5-HTP on weight loss in obese women. In this double-blind, placebo-controlled study, 20 participants received either 5-HTP or a placebo for two weeks. The results showed that 5-HTP reduced calorie intake and led to significant weight loss [10] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → .
In 1998, another study was conducted to investigate the effects of 5-HTP on weight loss. The double-blind, placebo-controlled study involved 20 obese participants who received either 5-HTP or a placebo for six weeks. The participants did not follow any specific diet. The study found that 5-HTP significantly reduced calorie intake and promoted weight loss [11] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → .
Green Tea Extract
We already talked about this earlier. The main active ingredient of Green Tea Extract is EGCG. It has strong antioxidant and anti-inflammatory properties, which may protect cells from damage, suppress the activity of pro-inflammatory chemicals, and reduce the risk of chronic diseases such as heart disease, cancer, and diabetes; it may also promote weight loss, especially when taken alongside caffeine, and may improve neurological cell function and prevent degenerative brain diseases.
NatureWise Pure Garcinia Cambogia
NatureWise is a California-based supplement company founded in 2012. Its Pure Garcinia Cambogia is a natural weight loss supplement that supports metabolism and appetite management. The potent extract is derived from the rind of the Garcinia Cambogia fruit and contains 60% Hydroxycitric acid (HCA), the active ingredient that has been clinically shown to block excess carbs and sugars from being stored as fat and increase serotonin levels, which can help reduce emotional food cravings.
NatureWise’s Garcinia Cambogia is plant-based, non-stimulating, and free from artificial additives or fillers. The product is third-party tested for purity, ensuring the highest quality and efficacy.
Ingredients
| Ingredients | Per Capsule |
|---|---|
| Garcinia Cambogia Extract (60% HCA) | 500mg |
| Total Hydroxycitric Acid | 300mg |
Scientific Research
Garcinia Cambogia is a tropical fruit that is native to Southeast Asia and India. It contains a compound called hydroxycitric acid (HCA), which is believed to have several health benefits, including weight loss control, lowering cholesterol, regulating blood sugar and anti-inflammatory effects.
(Image: Vssun at ml.wikipedia)
In a 2010 meta-analysis published on the Journal of Obesity, researchers reviewed 23 randomized clinical trials, with 12 meeting the criteria for inclusion, and 9 providing data suitable for statistical pooling. The analysis revealed a small but statistically significant difference in weight loss favoring HCA over a placebo. However, the study also concludes that the magnitude of the effect is small, the clinical relevance is uncertain, and that future trials should be more rigorous and better reported [12] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → .
How to Use
- Standard serving: Adults take 1 capsule, three times daily, 30 minutes to 2 hours before meals, with a full glass of water.
- Maximum serving: Adults take 3 capsule, three times daily, 30 minutes to 2 hours before meals, with a full glass of water.
Potential Side Effects
- Cases of liver damage associated with the use of garcinia cambogia products have been reported. This problem appears to be uncommon, but some cases were severe. Most of the reported cases involved products labeled as containing a combination of ingredients, but some involved products labeled as containing only garcinia cambogia[13] Trusted Website U.S. National Center for Complementary and Integrative Health Open the link → .
- Other side effects associated with garcinia cambogia include headache and nausea, diarrhea, and other gastrointestinal symptoms.
- Little is known about whether it’s safe to use garcinia cambogia during pregnancy or while breastfeeding.
Relora™ (for Stress Caused Overeat)
The stress hormone, called cortisol, can cause an increase in appetite, leading people to overeat. A 2018 study in Turkey involving 107 students between 19 and 23 years found that the mean cortisol level increased approximately 9 times in stressful periods compared with that in relaxed periods [14] Trusted Website NCBI, US National Center for Biotechnology Information, is a trusted source of biotechnology and biomedicine information. Open the link → .
Relora™ is a blend of plant extracts from Magnolia officinalis and Phellodendron amurense, which supports healthy cortisol levels within the normal range and helps manage weight by controlling stress-related eating and appetite. It is a non-sedating supplement that has been clinically validated to support the body’s response to minor, temporary stress, which can result in nervous tension, irritability, fatigue, sadness, and nervous eating.
NOW Supplements’ Relora™ pills are kosher, soy-free, vegan/vegetarian, egg-free, dairy-free, and made without gluten, and is packaged in the USA. NOW Supplements is a family owned business since 1968 and is based in Illinois.
Ingredients
| Ingredients | Per Serving |
|---|---|
| Relora™ | 300mg |
How to Use
Take 1 capsule, 2 to 3 times daily.
Scientific Research
In a 2006 study, 28 women between the ages of 20 and 50, who typically ate more when stressed, were given either Magnolia and Phellodendron extract or a placebo three times a day for six weeks. Results showed that those taking the supplement did not experience significant weight gain, while those taking the placebo did. The supplement was also found to lower cortisol levels, which are associated with stress, in the treatment group [15] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → .
In a 2013 study, 56 people (35 men and 21 women) were either given Relora or a placebo for 4 weeks. Results showed that the group taking Relora had significantly lower cortisol exposure and improved mood parameters, including less stress, tension, depression, anger, fatigue, and confusion, and higher global mood state and vigor [16] Trusted Website NCBI, US National Center for Biotechnology Information, is a trusted source of biotechnology and biomedicine information. Open the link → .
Potential Side Effects
No known side effects are listed. The manufacture cautioned that it is for adults only; do not take if you’re pregnant of nursing.
Transparent Labs “Fat Burner” Pills
Transparent Labs is an Utah-based supplements company founded in 2015. Its PhysiqueSeries “Fat Burner” is an all-natural dietary supplement designed to help you expedite weight loss by controlling cravings, boosting metabolism, and facilitating lipolysis and fatty acid oxidation. It contains a blend of ingredients that have been scientifically proven to increase fat burning, suppress appetite, and improve mood, such as Green Tea Extract, Caffeine, Forskolin, 5-HTP, L-Tyrosine, L-Theanine, cayenne pepper extract. However, caution has been noted about Synephrine.
Key Benefits
- All-natural ingredients
- Suppresses appetite and burns fat at the same time
- Facilitates lipolysis and fatty acid oxidation for efficient fat burning
- Increases metabolism
- Helps maintain muscle mass while losing body fat
- Promotes a healthy mood and enhances focus
- Suitable for an enjoyable weight loss lifestyle
- Third-party tested for purity, potency, and authenticity
Ingredients
| Ingredients | Per serving |
|---|---|
| Forslean (10% forskolin) | 500mg |
| Green Tea (50% EGCG) | 400mg |
| 5-HTP | 300mg |
| L-Tyrosine | 300mg |
| L-Theanine | 240mg |
| Caffeine Anhydrous | 240mg |
| Salicin (White Willow) Bark | 120mg |
| Cayenne Pepper Extract | 100mg |
| Synephrine HCl | 50mg |
How to Use
- Take 2 capsules with 8-10 ounces of water, twice daily, 30-60 minutes before meals.
- Start with 1 capsule, twice daily, to assess tolerance for the first 3 days, then gradually increase dosage.
- Never consume more than 2 capsules in a 4-hour period and/or consume more than 4 capsules in a 24-hour period. Do not take it within 4 hours of bedtime.
Scientific Research
Forslean (Forskolin)
Forslean is an extract from the roots of the Coleus forskohlii plant. Its active ingredient is called forskolin. Coleus forskohlii is a plant from the mint family that grows in tropical regions of Asia, such as Nepal, India, and Thailand.
In a study published in the journal Obesity Research in 2005, researchers investigated the effects of a forskolin-containing supplement on body composition and appetite in overweight and obese men. The study found that after 12 weeks of supplementation, the participants had significant reductions in body weight and body fat percentage, as well as decreased hunger and increased feelings of fullness [17] Trusted Website Wiley.com is a U.S. publishing company that specializes in academic content with 200 years of history. Open the link → .
Green Tea Extract (EGCG)
As discussed earlier, the main active ingredient of green tea extract is EGCG (Epigallocatechin Gallate), which is a type of catechin. EGCG has strong antioxidant and anti-inflammatory properties, which may protect cells from damage, suppress the activity of pro-inflammatory chemicals, and reduce the risk of chronic diseases such as heart disease, cancer, and diabetes; EGCG may also promote weight loss, especially when taken alongside caffeine, and may improve neurological cell function and prevent degenerative brain diseases.
5-HTP
As discussed earlier, 5-HTP is a natural amino acid precursor that is used by the body to produce serotonin, a neurotransmitter that regulates mood, appetite, and sleep.
Caffeine Anhydrous
As discussed earlier, Caffeine Anhydrous is a concentrated, powdered form of caffeine that is commonly used to improve alertness and mental focus.
Cayenne Pepper Extract
As discussed earlier, Cayenne Pepper Extract is a concentrated liquid or powder made from chili pepper, commonly used in cooking and for its potential health benefits, particularly could be beneficial for weight loss and weight maintenance.
Salicin (White Willow) Bark
White willow bark has been used for centuries in China and Europe to treat pain, inflammation, and fever. The bark contains a chemical called salicin, which is similar to aspirin and is believed to be responsible for the pain-relieving and anti-inflammatory effects of the herb.
(Image: Frontier Co-op Store at Amazon)
Willow bark also appears to relieve headaches and back pain, and can be useful for osteoarthritis. However, people who are allergic or sensitive to salicylates (such as aspirin), or who have certain medical conditions, should avoid taking willow bark.
L-Tyrosine
L-Tyrosine is a nonessential amino acid produced by the body from phenylalanine. It is important for the production of several neurotransmitters that help nerve cells communicate, influencing mood. Some studies suggest that tyrosine supplements may improve memory and performance under psychological stress and may help increase alertness after sleep deprivation. However, further research is needed to confirm these findings.
Tyrosine is found in soy products, chicken, fish, peanuts, and dairy products, and is also available as a dietary supplement in capsule or tablet form. If you have a medical condition, take medication, or have migraine headaches or hyperthyroidism, you should talk to your doctor before taking tyrosine supplements.
L-Theanine
Theanine is an amino acid found in tea and some mushrooms that is sometimes used to improve mental function, reduce anxiety and stress, and enhance cognitive function.
While there is some evidence to suggest that taking L-theanine by mouth might help healthy people stay focused, there is not enough reliable information to support many of the other potential uses for theanine.
Theanine is generally considered safe when used short-term. However, there is not enough evidence to know if it is safe for long-term use, and it may cause mild side effects like headaches or sleepiness. Theanine may also interact with some medications, including those for high blood pressure and sedatives, so caution should be used when taking theanine in conjunction with these medications.
Synephrine HCl
Synephrine is a compound found in bitter orange, a small tree that bears fruit sometimes used in small amounts in food as a flavorant and often used in pre-workout and weight-loss supplements. Synephrine is similar to ephedra, a substance that was banned by the FDA due to its serious effects on the heart.
(Image: A. Barra at Wikimedia)
There are some concerns about the safety of synephrine, as adverse events such as chest pain, increased heart rate, and stroke have been reported in association with dietary supplements containing synephrine. While the data to support these concerns are not strong, U.S. DoD’s Operation Supplement Safety program advised service members to err on the side of caution when considering whether to use supplements containing synephrine, and warned that synephrine might register on an initial military urine screening test for amphetamines, although it will not cause a positive result on confirmation drug tests[18].
Potential Side Effects
The product contains caffeine and synephrine HCl, which are stimulants and may cause side effects such as jitteriness, anxiety, and difficulty sleeping. Additionally, cayenne pepper may affect people with a sensitivity to nightshades. People with caffeine sensitivity or autoimmune conditions should consult with a healthcare professional before taking this supplement.
Medication for Appetite & Weight Control
Prescription appetite suppressants can be effective when combined with a healthy diet and exercise, leading to a weight loss of 3% to 9% of the starting weight within 12 months. Some people may benefit from using appetite suppressants as a jumpstart to weight loss and to learn to recognize cues that signal when they are full.
It is important to note that using appetite suppressants should not be the sole method of weight loss and should be combined with lifestyle changes for best results. Also, appetite suppressants can have side effects and are not recommended for everyone, including those with certain medical conditions or who are pregnant or breastfeeding.
The Food and Drug Administration (FDA) has approved these prescription appetite suppressants:
- Diethylpropion (Tenuate dospan(R)).
- Liraglutide (Saxenda(R)).
- Naltrexone-bupropion (Contrave(R)).
- Phendimetrazine (Prelu-2(R)).
- Phentermine (Pro-Fast(R)).
- Phentermine/topiramate (Qsymia(R)).
If your ultimate goal is to lose weight and keep fit, Alli(R) is a widely used over-the-counter weight loss aid developed by GlaxoSmithKline. It is the only FDA-approved non-prescription weight loss product available in the United States. Its active ingredient, orlistat, has been clinically proven to help individuals lose weight effectively and safely.
Alli works by blocking the absorption of dietary fats in the body, which in turn reduces the number of calories consumed. The main component, orlistat, inhibits the action of lipase enzymes in the gastrointestinal tract, preventing the breakdown and absorption of fat from food. As a result, the unabsorbed fat is excreted through the digestive system, leading to weight loss [19] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → .
The FDA approved Alli for over-the-counter use in 2007. Customer reviews of Alli have been generally positive, with many users experiencing significant weight loss over time. Alongside a reduced-calorie, low-fat diet and regular exercise, Alli has helped countless people reach their weight loss goals. However, it is essential to note that results may vary, and some users may experience side effects, such as gastrointestinal discomfort.
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