A Guide to the Top 8 Weight Loss Supplements and OTC Pills of 2023

ES Fil FR KO VI

Weight loss can be a challenging process, and sometimes it’s hard to know where to turn for help. That’s where dietary supplements come in! These nutritional aids have been designed to assist you in your weight loss journey by complementing your existing diet and exercise efforts. In this article, we will delve into the top dietary supplements for weight loss, backed by scientific research and real-life choices.

Green Tea Extract

Green tea extract is derived from the leaves of the Camellia sinensis plant and is rich in antioxidants called catechins, particularly epigallocatechin gallate (EGCG). It is believed to increase energy expenditure and fat oxidation, which may help with weight loss [1] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . However, some studies have shown mixed results, and more research is needed to confirm its effectiveness [2] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . Possible side effects include digestive issues, liver problems, and interactions with certain medications [3] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → .

Green Tea Weight Loss Pills with Green Coffee Bean Extract | Belly Fat Burner, Metabolism Booster, & Appetite Suppressant for Women & Men |...
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NOBI Nutrition Green Tea Extract Pills, 60 capsules

Nobi Nutrition’s Green Tea Extract “Fat Burner” is a vegan, non-GMO and gluten-free weight loss supplement designed to help both women and men reduce belly fat and manage their weight. Key ingredients include 200 mg of Green Tea with 45% EGCG, a proprietary blend of green coffee bean extract and garcinia cambogia, which work together to increase thermogenesis, suppress appetite, and support detox and healthy digestion. It’s manufactured in the U.S.A following GMP guidelines, and it’s keto- and paleo-friendly. Simply take two capsules each morning on an empty stomach.

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Conjugated Linoleic Acid (CLA)

CLA is a naturally occurring fatty acid found in meat and dairy products. Some studies have shown that CLA supplementation may help reduce body fat and increase lean body mass [4] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . However, the effect on weight loss is modest, and long-term safety is unclear [5] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . Possible side effects include gastrointestinal issues, increased inflammation, and potential negative impacts on insulin sensitivity [6] Trusted Website NCBI, US National Center for Biotechnology Information, is a trusted source of biotechnology and biomedicine information. Open the link → .

NatureWise CLA 1250 - CLA Supplement with Conjugated Linoleic Acid for Women and Men, Non-Stimulating CLA, Supports Healthy Weight, Fitness...
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NatureWise CLA 1250, 180 capsules

NatureWise CLA 1250 is a natural exercise enhancement supplement that supports lean muscle mass and promotes energy. It contains conjugated linoleic acid (CLA), which may encourage greater benefits from exercise by influencing the activity of certain enzymes that play a role in the metabolism of fatty acids. NatureWise CLA is made with clean, simple, natural ingredients that are non-stimulating, non-addictive, and safe for long-term use. It comes from pure, premium-quality, non-GMO safflower oil obtained from certified sources and standardized to a high potency of 80%. Each 1250 mg softgel contains 1000 mg of CLA.

Glucomannan

Glucomannan is a soluble fiber derived from the roots of the konjac plant. It works by absorbing water in the stomach, creating a feeling of fullness, which may help reduce food intake [7] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . Some studies have shown moderate weight loss effects, but more research is needed [8] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . Possible side effects include bloating, flatulence, and potential choking hazards if not taken with sufficient water [9] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → .

Nutricost Glucomannan 1,800mg Per Serving, 180 Capsules - Natural Fiber Source, Non-GMO, Gluten Free
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Nutricost Glucomannan 1,800 mg, 180 capsules

Nutricost Glucomannan is a high-quality dietary supplement that provides 1,800 mg of glucomannan per serving (600 mg per capsule, 3 capsules per day) and is derived from konjac root. This soluble, bulk-forming fiber has been shown to support healthy digestion and weight management when taken with water before meals. The capsules are non-GMO and gluten-free, and are made with only high-quality glucomannan. The product is manufactured in a GMP compliant, FDA registered facility. The recommended serving is three capsules daily with 8-12 oz of water.

Caffeine

Caffeine is a stimulant found in coffee, tea, and many other products. It may help with weight loss by increasing metabolism and enhancing fat oxidation [10] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . However, its effects on weight loss tend to be modest, and tolerance to its effects may develop over time [11] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . Possible side effects include increased heart rate, elevated blood pressure, insomnia, and nervousness [12] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → .

Nutricost Caffeine Pills, 200mg Per Serving (250 Caps)
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Nutricost Caffeine Pills, 200 mg, 250 capsules

Nutricost Caffeine Pills offer a high-quality source of caffeine without the added sugar or calories found in energy drinks. With 200 mg of caffeine per capsule, these pills are perfect for those who need an extra boost to power through their day, whether it be for athletic performance, workouts, or daily tasks. The pills are non-GMO and gluten-free, and are made in a GMP compliant, FDA registered facility. Nutricost is a U.S.-based company that produces premium quality nutritional supplements and vitamins.

Garcinia Cambogia

Garcinia Cambogia is a tropical fruit extract containing hydroxycitric acid (HCA), which is believed to block an enzyme that helps produce fat and increase serotonin levels, potentially reducing appetite [13] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . Studies on its effectiveness for weight loss have shown mixed results, and more research is needed [14] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . Possible side effects include liver toxicity, digestive issues, and potential interactions with medications [15] Trusted Website NCBI, US National Center for Biotechnology Information, is a trusted source of biotechnology and biomedicine information. Open the link → .

Naturewise Garcinia Cambogia with Pure Garcinia Cambogia Extract, 60% HCA Concentration, Natural Support for Weight Goals and Energy -...
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NatureWise Pure Garcinia Cambogia, 300 mg HCA, 180 capsules

NatureWise Pure Garcinia Cambogia is a 100% natural and plant-based supplement that contains a concentrated extract of garcinia cambogia with 60% HCA to support metabolic processes and discourage cravings. This potent natural extract has been shown to block excess carbs and sugars from being stored as fat and increase serotonin levels to reduce emotional food cravings. Unlike other weight loss supplements, it is non-stimulating and contains no artificial additives or fillers. The recommended serving is one capsule three times daily, taken 30 minutes to 2 hours before meals with a full glass of water.

Raspberry Ketones

Raspberry ketones are natural compounds found in red raspberries that are believed to increase adiponectin levels, a hormone that may help regulate metabolism and break down fat [16] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . However, the evidence for weight loss in humans is limited, and most studies have been conducted on animals [17] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . Possible side effects include increased heart rate, blood pressure, and potential interactions with medications [18] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → .

Keto BHB Exogenous Ketones for Men & Women - Keto Supplements for Mental Clarity & Focus - Keto Burn - Keto Fat Burner - Keto Pills...
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Nutriana Keto Pills, 60 Capsules

Nutriana’s Keto BHB Pills is a supplement designed to help people achieve ketosis, a state where the body burns fat for energy instead of carbohydrates. The product contains beta-hydroxybutyrate (BHB) which is a natural energy produced during ketosis. It can help your keep a low-carb keto diet and potentially experience benefits such as reduced hunger, improved mental clarity, and sustained energy throughout the day. Made in the U.S. with ISO-accredited laboratories. Recommended 2 capsules per day, taken with water before a meal.

5-HTP (5-Hydroxytryptophan)

5-HTP is a naturally occurring amino acid and a precursor to serotonin, which is associated with mood regulation and appetite control [19] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . Some studies have shown that 5-HTP supplementation may help reduce appetite and promote weight loss [20] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . However, more research is needed to establish its effectiveness. Possible side effects include gastrointestinal issues, drowsiness, and interactions with antidepressant medications.

DR EMIL NUTRITION 200 MG 5-HTP Plus with SAM-e to Maintain Normal Healthy Sleep and Create a Sense of Wellbeing - 5HTP Supplement with...
24,607 Reviews
Dr. Emil Nutrition 5-HTP Plus 200 mg, 60 capsules

Dr. Emil Nutrition’s 200 mg 5-HTP Plus Formula is a natural, vegan supplement. It contains a combination of 200 mg pure 5-HTP, 20 mg SAMe, 20 mg L Tryptophan, and vitamin B6 to optimize 5-HTP conversion. Vitamin B6 aids 5-HTP conversion, and studies have shown that a slight deficiency of B6 can greatly inhibit the efficacy of 5-HTP. Recommended 2 capsules per day. Each bottle has 60 capsules, providing 30 days of support.

Forskolin

Forskolin is an extract from the root of the coleus forskohlii plant, which has been studied for its potential effects on fat metabolism and weight loss [21] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . Some studies have suggested that forskolin may help promote fat loss and increase lean body mass [22] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → . However, more research is needed to confirm its effectiveness. Possible side effects include low blood pressure, increased heart rate, and interactions with medications [23] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → .

Vitamin Bounty Forskolin Max Strength - Forskolin Extract, Forskolin Supplement, Forskohlii Coleus Supplement, Coleus Forskohlii Extract,...
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Vitamin Bounty Forskolin, 500mg, 60 capsules

Vitamin Bounty Forskolin Max Strength is a plant-based supplement that contains forskolin extract, derived from the coleus forskohlii plant. This supplement is designed to help support a healthy lifestyle by reducing excessive cravings and potentially aiding in the regulation of metabolism. Forskolin is believed to stimulate an increase in cAMP levels in the body, which may help break down sugars and fat. This supplement is vegan, gluten-free, dairy-free, non-GMO, and made in the U.S. in a GMP facility.

Bonus: Alli (OTC Medicine)

Alli is a widely used over-the-counter weight loss aid developed by GlaxoSmithKline. It is the only FDA-approved non-prescription weight loss product available in the United States. Its active ingredient, orlistat, has been clinically proven to help individuals lose weight effectively and safely.

Alli works by blocking the absorption of dietary fats in the body, which in turn reduces the number of calories consumed. The main component, orlistat, inhibits the action of lipase enzymes in the gastrointestinal tract, preventing the breakdown and absorption of fat from food. As a result, the unabsorbed fat is excreted through the digestive system, leading to weight loss [24] Trusted Website PubMed is a data base from US National Institutes of Health. It’s a trusted source of health and medical information. Open the link → .

alli Weight Loss Diet Pills, Orlistat 60 mg Capsules, Non Prescription Weight Loss Aid, 120 Count Refill Pack
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alli Weight Loss Diet Pills, 120 capsules

The FDA approved Alli for over-the-counter use in 2007. Customer reviews of Alli have been generally positive, with many users experiencing significant weight loss over time. Alongside a reduced-calorie, low-fat diet and regular exercise, Alli has helped countless people reach their weight loss goals. However, it is essential to note that results may vary, and some users may experience side effects, such as gastrointestinal discomfort.

24 references

[1]. Hursel R, Viechtbauer W, Westerterp-Plantenga MS. The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int J Obes (Lond). 2009 Sep;33(9):956-61. doi: 10.1038/ijo.2009.135. Epub 2009 Jul 14. PMID: 19597519.

[2]. Jurgens, T. M., Whelan, A. M., Killian, L., Doucette, S., Kirk, S., & Foy, E. (2012). Green tea for weight loss and weight maintenance in overweight or obese adults. Cochrane Database of Systematic Reviews, (12).

[3]. Mazzanti, G., Di Sotto, A., & Vitalone, A. (2015). Hepatotoxicity of green tea: an update. Archives of toxicology, 89(8), 1175-1191.

[4]. Whigham, L. D., Watras, A. C., & Schoeller, D. A. (2007). Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. The American journal of clinical nutrition, 85(5), 1203-1211.

[5]. Onakpoya, I., Posadzki, P., & Ernst, E. (2012). The efficacy of long-term conjugated linoleic acid (CLA) supplementation on body composition in overweight and obese individuals: a systematic review and meta-analysis of randomized clinical trials. European journal of nutrition, 51(2), 127-134.

[6]. Lehnen, T. E., da Silva, M. R., Camacho, A., Marcadenti, A., & Lehnen, A. M. (2015). A review on effects of conjugated linoleic fatty acid (CLA) upon body composition and energetic metabolism. Journal of the International Society of Sports Nutrition, 12(1), 1-11.

[7]. Keithley, J., & Swanson, B. (2005). Glucomannan and obesity: a critical review. Alternative therapies in health and medicine, 11(6), 30-34.

[8]. Onakpoya, I., Posadzki, P., & Ernst, E. (2014). The efficacy of glucomannan supplementation in overweight and obesity: a systematic review and meta-analysis of randomized clinical trials. Journal of the American College of Nutrition, 33(1), 70-78.

[9]. Sood, N., Baker, W. L., & Coleman, C. I. (2008). Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis. The American journal of clinical nutrition, 88(4), 1167-1175.

[10]. Westerterp-Plantenga, M. S., Lejeune, M. P., & Kovacs, E. M. (2005). Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obesity research, 13(7), 1195-1204.

[11]. Astrup, A., Toubro, S., Cannon, S., Hein, P., Breum, L., & Madsen, J. (1990). Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. The American journal of clinical nutrition, 51(5), 759-767.

[12]. Nawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A., & Feeley, M. (2003). Effects of caffeine on human health. Food Additives & Contaminants, 20(1), 1-30.

[13]. Onakpoya, I., Hung, S. K., Perry, R., Wider, B., & Ernst, E. (2011). The use of Garcinia extract (hydroxycitric acid) as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials. Journal of obesity, 2011.

[14]. Heymsfield, S. B., Allison, D. B., Vasselli, J. R., Pietrobelli, A., Greenfield, D., & Nunez, C. (1998). Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. Jama, 280(18), 1596-1600.

[15]. Lunsford, K. E., Bodzin, A. S., Reino, D. C., Wang, H. L., & Busuttil, R. W. (2016). Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation. World journal of gastroenterology, 22(45), 10071.

[16]. Morimoto, C., Satoh, Y., Hara, M., Inoue, S., Tsujita, T., & Okuda, H. (2005). Anti-obese action of raspberry ketone. Life sciences, 77(2), 194-204.

[17]. Lopez, H. L., Ziegenfuss, T. N., Hofheins, J. E., Habowski, S. M., Arent, S. M., Weir, J. P., & Ferrando, A. A. (2013). Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. Journal of the International Society of Sports Nutrition, 10(1), 1-14.

[18]. Wang, L., Meng, X., & Zhang, F. (2012). Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. Journal of medicinal food, 15(5), 495-503.

[19]. Birdsall, T. C. (1998). 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Alternative medicine review, 3(4), 271-280.

[20]. Cangiano, C., Ceci, F., Cairella, M., Cascino, A., Del Ben, M., Laviano, A., … & Rossi-Fanelli, F. (1992). Effects of 5-hydroxytryptophan on eating behavior and adherence to dietary prescriptions in obese adult subjects. Advances in experimental medicine and biology, 294, 591-593.

[21]. Godard, M. P., Johnson, B. A., & Richmond, S. R. (2005). Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obesity research, 13(8), 1335-1343.

[22]. Loftus, H. L., Astell, K. J., Mathai, M. L., & Su, X. Q. (2015). Coleus forskohlii extract supplementation in conjunction with a hypocaloric diet reduces the risk factors of metabolic syndrome in overweight and obese subjects: a randomized controlled trial. Nutrients, 7(11), 9508-9522.

[23]. Alasbahi, R. H., & Melzig, M. F. (2012). Forskolin and derivatives as tools for studying the role of cAMP. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 67(1), 5-13.

[24]. Rucker D, Padwal R, Li SK, Curioni C, Lau DC. Long term pharmacotherapy for obesity and overweight: updated meta-analysis. BMJ. 2007 Dec 8;335(7631):1194-9. doi: 10.1136/bmj.39385.413113.25. Epub 2007 Nov 15. Erratum in: BMJ. 2007 Nov 24;335(7629). doi: 10.1136/bmj.39406.519132.AD. PMID: 18006966; PMCID: PMC2128668.

Derek Yang

I'm an immigrant living with my family in a small town on the East Coast. I love classical music, enjoy a good cup of coffee, and have a soft spot for BMWs. I believe in lifelong learning and look forward to connecting with you to share our life experiences. Twitter @mrderekyang.

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